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Research Paper | Pharmacology and Toxicology | India | Volume 12 Issue 5, May 2023 | Rating: 5.1 / 10
Drug Utilization Study of Antimicrobial Agents in the Indoor Patient of the Medicine Department in a Tertiary Care Hospital - A Prospective Observational Study
Dr. Reena R. Giri | Dr. Syed Faizan Syed Aslam | Dr. Girish K. Chavhan
Abstract: Background: In developing countries irrational use of antimicrobials agents in the healthcare system has been observed, thus this study was conducted to assess the prescribing patterns of antimicrobial agents in general medicine wards of a tertiary health care center in Central India. Materials and Methods: A prospective observational study was conducted over a period of 18 months. Standard proforma was used to collect information regarding socio - demographic factors, route, dose, indications of antimicrobial agents. Data was analyzed with help of Microsoft excel 2010 and expressed as percentage. Results: Total 900 cases were studied. Majority of the patients 319 (35.44%) belonged to 21 - 40 years age group of which 538 (59.77%) were males. Most of the patients 561 (62.33%) were from Urban areas. Most antimicrobial agents were administered Intravenously (1644, 91.44%). Most commonly prescribed anti - microbial agent was Ceftriaxone 539 (29.97%) followed by Piperacillin - Tazobactam 230 (12.79%), Amoxiclav 198 (11.01%), Artesunate 203 (11.29%),, Metronidazole 195 (10.84%). Most of the antimicrobial agents 1557 (86.59%) were prescribed by brand names. The antimicrobial agents prescribed as monotherapy were 224 (12.45%) and as FDCs were 455 (25.30%). Majority of the patients 526 (58.44%) were prescribed two antimicrobial agents. Out of the total number of antimicrobials prescribed 80.92% were from the Essential Medicine List. Conclusion: A variety of antimicrobials were utilized from various antimicrobial classes. The number of antimicrobials prescribed by generic names was low. An effort must be made to encourage prescribing by generic names. Rational use of antimicrobial agents should be encouraged by following strict Hospital antimicrobial policy. Polypharmacy was noted which may be related to drug - drug interactions and adverse drug reactions. So, polypharmacy should be discouraged.
Keywords: Antimicrobials, Generic, Essential Medicines, Polypharmacy
Edition: Volume 12 Issue 5, May 2023,
Pages: 200 - 204