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Analysis Study Research Paper | Medicine and Dentistry | India | Volume 12 Issue 5, May 2023 | Popularity: 5.3 / 10

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Reaffirming the Peripheral Action of Local Anaesthesia (LA): A Prospective Clinical Study

Dr. B L Himaja Reddy, Dr. Kavitha Prasad, Dr. Vineeth Kumar K, Dr. Sanah Tazeen, Dr. Rajanikanth B.R, Dr Parimala Sagar, Dr. K Ranganath

Abstract: Background: As per existing literature Local Anaesthetics (LA) had only peripheral action .In study by All saffar et.al poskulated that the opiorphins in saliva were elevated after the administration of Local Anaesthetic(LA) .To investigate the proposed central mechanism of LA this study was conducted. Purpose: To investigate the proposed Central mechanism of action of Local anaesthetic and association with salivary opiorphin?s. Study Design: This was a prospective study done in the Department of Oral and Maxillofacial Surgery, FDS, Ramaiah University of Applied Sciences, Bangalore in patient milieu of 44 patients (22 males, 22 females), aged between 18-69years, indicated for prophylactic extractions under Local Anaesthesia between November 2019 to February 2021. Predictor: salivary opiorphin?s assesses to be increased after administration of Local Anaesthetics. Main outcome variable(s): The mean levels of salivary opiorphin?s were decreased and increased but ranged in normal limit. Analyses: The P value was 0.96, with no statistical significance. Results: The mean level of salivary opiorphin?s before was 28.38ng/ml and 26.24ng/ml, after administration of local anaesthesia. Therefore, there was a mean decrease of 2.14ng/ml in salivary opiorphin levels after administration of LA. The P value was 0.96, with no statistical significance. Conclusion: Our study results indicate that local anaesthetics have only peripheral action. There was a mean decrease in opiorphin levels after administration of local anaesthesia. The change in opiorphin levels was not statistically significant; negating any association between administration of local anaesthesia (2% lignocaine hydrochloride) by IANB technique and salivary opiorphin levels.

Keywords: Salivary opiorphin's ,opiorphin's, Endorphin's Neuroectopeptidases ,Central Mechanism of action

Edition: Volume 12 Issue 5, May 2023

Pages: 211 - 218

DOI: https://www.doi.org/10.21275/SR23502142952

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