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Review Papers | Health and Medical Sciences | India | Volume 12 Issue 6, June 2023 | Popularity: 4.9 / 10

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In Silico Clinical Trials - Review

Dr. Samuel Santhosh, Dr. R Divya

Abstract: In silico clinical trials (ISCTs) represent a game - changing advancement in medical research and have the potential to revolutionize the development and evaluation of therapies. By utilizing computational models and simulations, ISCTs offer a cost - effective and time - efficient alternative to traditional clinical trials. They provide a virtual testing ground to assess the safety, efficacy and dosage optimization of interventions, while minimizing ethical concerns associated with human trials. The versatility of ISCTs spans across various medical fields, enabling researchers to explore personalized medicine approaches and refine treatment strategies. Although challenges remain in accurately representing human physiology within computational models, ongoing advancements in data integration and validation techniques are rapidly improving the reliability and predictive capabilities of ISCTs. Overall, in silico clinical trials hold immense promise for accelerating therapeutic development, enhancing patient care and driving the future of medical research. This review article provides an in - depth overview of various ISCTs types, its advantages, limitations and their applications in drug development from the existing literatures.

Keywords: In silico clinical trials, Pharmacokinetic modeling, pharmacodynamic modeling, Virtual patient populations, Machine learning, artificial intelligence, Model - based drug development

Edition: Volume 12 Issue 6, June 2023

Pages: 262 - 266

DOI: https://www.doi.org/10.21275/SR23512133636

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