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Research Paper | Medicine | India | Volume 12 Issue 6, June 2023 | Rating: 5.2 / 10
Clinical and Biochemical Profile and Outcome in Scrub Typhus Positive Patients
Nidhi Chaurasia | Azhar Ali Khan | Sudheer Yadav
Abstract: Introduction: Scrub typhus (Tsutsugamushi disease) is an acute (<2 weeks duration), febrile, and infectious illness caused by Orientia tsutsugamushi and transmitted by chiggers. The disease is endemic in South Asia, with reports of re - emergence from various regions in India. The present study aimed to study the clinical and biochemical profile, and outcome in cases of scrub typhus. Methodology: This hospital - based observational study included 240 patients of age 17 years and above with acute febrile illness with <2 weeks? duration with or without altered sensorium were included in the study. Clinico - demographical, and biochemical parameters, along with outcomes, were recorded. Results: Out of 240 patients, 89 (35.08%) were confirmed to haveScrub typhus. Most of them were females (51.69%) and belonged to the lower class (34.83%). Fever of >1 week (86.52%), altered sensorium (43.82%), and icterus (59.55%) were the predominant clinical features. Hepatomegaly and splenomegaly were also reported. Diabetes (n=7) and hypertension (n=5) were the common comorbidities. The majority of the patients (n=41) had GCS of 11 - 15, of which 100% were survivors. Mortality (73.34%) was significantly found in those withGCS 3 - 6. Overall, the fatality was 14.60%. A significant difference was noted in haematological parameters. The majority of the non - survivors had total serum bilirubin>3mg/dl (n=6), creatinine>3mg/dl (n=8). A significantly negative correlation was also noted between Outcomes and serum creatinine (r= - 0.3569). Furthermore, the sensitivity (69.23%) and specificity (59.21%) at a cut - off value of Serum Creatinine < 1.395 was observed with a maximum Likelihood ratio of 1.967. Conclusion: According to the results of the present study, TLC, serum creatinine, platelet counts, and total serum bilirubin can be utilized to predict fatality.
Keywords: Scrub Typhus, Febrile illness, Splenomegaly, Platelet count, Mortality
Edition: Volume 12 Issue 6, June 2023,
Pages: 903 - 909