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Research Paper | Medicine | India | Volume 12 Issue 6, June 2023 | Popularity: 4.9 / 10

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For the Prediction of Infected Pancreatic Necrosis and Mortality in Patients with Acute Pancreatitis, Interleukin-6 is better than C-Reactive Protein

Dr. R. K. Chaitanya Reddy, Dr. R. Selva Sekaran, Dr. Shirish .N .D

Abstract: Introduction: This study aimed to identify whether interleukin-6 (IL-6) is better than C-reactive protein (CRP) for the prediction of severe acute pancreatitis (SAP), infected pancreatic necrosis (IPN), and mortality. Methods: Sixty-seven patients with acute pancreatitis (AP) who were hospitalized within 48 h of onset and received serum CRP and IL-6 tests from September 2020 to September 2021 were included. Spearman?s correlation was performed to assess their associations with severity. The areas under the curve (AUCs) for the prediction of SAP, organ failure, pancreatic necrosis, IPN, and mortality were estimated using receiver operating characteristic curves. Result: Serum CRP and IL-6 levels were significantly positively correlated with the severity of AP (p < 0.05). The AUC for the prediction of SAP based on the CRP level was 0.76 (95% CI, 0.64?0.87) and that based on the IL-6 level was 0.68 (95% CI, 0.58?0.84). For the prediction of organ failure and pancreatic necrosis, CRP was more accurate than IL-6 (AUC 0.81 vs. 0.70 and 0.75 vs. 0.68, respectively). However, CRP was less accurate than IL-6 for predicting mortality and IPN (AUC 0.70 vs. 0.76 and 0.66 vs. 0.80, respectively). Systemic inflammatory response syndrome plus CRP was more accurate than systemic inflammatory response syndrome plus IL-6 (AUC 0.78 vs. 0.74) for the prediction of SAP. Conclusions: IL-6 was more accurate than CRP for predicting mortality and IPN in patients with AP.

Keywords: C-reactive protein, interleukin 6, infected pancreatic necrosis, mortality, organfailure, severe acute pancreatitis

Edition: Volume 12 Issue 6, June 2023

Pages: 1141 - 1146

DOI: https://www.doi.org/10.21275/SR23607225448

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