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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 7, July 2023 | Rating: 5.4 / 10

Formulation and Development of Thymol Loaded Gum Acacia and Carbopol Crosslinked Hydrogel Wound Dressings

Nikhil S. Lohe | Rajashree .N. Lohe | Dr. Akhil S. Lohe

Abstract: Thymol, an antibacterial agent, was entrapped in acacia-carbopol (TAC) hydrogel films for rapid wound healing. Hydrogel was prepared by cross linking acacia and carbopol with N, N - methylenebis - (acrylamide). This hydrogel was further formulated into film (TAC) using solvent casting method and triethyl citrate as a plasticizer. Hydrogel and TAC films were characterized by NMR and FTIR. Both, the hydrogel and the films were evaluated for diffusion study of thymol which showed slow release of drug for wound healing. Antimicrobial activity of thymol against Pseudomonas aeruginosa was found to be retained in TCA film. Tensile strength and mucoadhesion of film performed using texture analyzer, showed elasticity and adhesiveness needed to retain on the wound area. High folding endurance confirmed flexibility of film. Films were also evaluated for degradation study, microbial penetration andrate of water vapor transmission. In vivo study of TCA film was performed using rats excision wound model which showed rapid wound healing and closure activity within day 10. Histology study revealed inflammatory cell infiltrations and neovascularization in granulation tissues, ultimately healing the wound. The mucoahesiveness of carbopol along with the antibacterial nature of thymol and astringent effect of acacia make the TCA film as a potential candidate for rapid wound healing.

Keywords: thymol, wound healing, hydrogel dressings

Edition: Volume 12 Issue 7, July 2023,

Pages: 411 - 420