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Research Paper | Medicine | India | Volume 12 Issue 7, July 2023 | Rating: 5.4 / 10
Estimation of Serum Albumin Level and its Prognostic Significance in Scrub Typhus Patients in Districts of Lower Assam
Dr. Neena Nath, Dr. Anamika Chaliha, Dr. Pavan Rajesh Kale, Dr. Aashish V, Dr. Simi Sehnaz
Abstract: Background & Objectives: Scrub Typhus, a zoonotic disease caused by a bacteria called Orientia tsutsugamushi is a reemerging disease and so this study aims to estimate the serum Albumin Levels in Scrub typhus patients and to determine its prognostic significance in scrub typhus patients in terms of complications, duration of hospital stay, ICU admission, recovery or death. Method: A hospital based observational, prospective study with a total no of 175 patients with Scrub typhus diagnosed as IgM positive were included in the study. Patients were divided in to three groups based on serum albumin level; Group1 - normal albumin (>3.5mg/dl), Group 2 - mild hypoalbuminemia (2.5 - 3.5mg/dl) and Group 3 - marked hypoalbuminemia (<2.5mg/dl). Patients were monitored daily for complications and outcome during hospital stay and observations of group 3 were compared with group 1 and 2. Results & Conclusions: 175 patients were included of which, 21 were categorized in group 1, 98 in 2, and 56 in 3 based on serum albumin level. Patients in group 3 had significantly higher incidence of Pleural effusion, Pneumonia, AKI, ARDS, and Meningoencephalitis compared to that of group 2 and 1. ICU admission was significantly high in group 3. Duration of hospital stay and mortality was significantly longer and higher in group 3 comparatively but not statistically significant. Patients with marked hypoalbuminemia in scrub typhus had higher incidence of complications, ICU admission and longer hospital stay as compared to normal albumin and considered to be a prognostic indicator of scrub typhus.
Keywords: Eschar, Orientia tsutsugamushi, hypoalbuminaemia, Acute kidney injury, Vasculitis
Edition: Volume 12 Issue 7, July 2023
Pages: 907 - 910