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Review Papers | Pharmacy | India | Volume 12 Issue 7, July 2023 | Rating: 4.9 / 10
Design and Characterization of Lercanidipine Microcrystals for Enhancement of Dissolution Rate
Abstract: Improved bioavailability is an added advantage for most of the poorly water soluble drugs. In recent years research work is concentrated on various methods to improve the solubility characteristics of poorly soluble drugs and crystallization phenomenon is one amongst them. The solubility problem can be solved by changing the crystal habit of drug, which improves the solubility and dissolution. So, in the present investigation an attempt has been made to improve the solubility characteristics of Lercanidipine HCl an anti - hypertensive drug, using solvent change method. In this method drug was dissolved in organic solvent (methanol) to form organic phase. Aqueous phase was prepared by dissolving stabilizing agents in water. Poloxamer 407 (1%) and Polyvinyl pyrollidone K30 (1.1%) are used as stabilizing agents. The formulated crystals of LercanidipineHCl were subjected to various physico - chemical parameters like size distribution, shape and surface characteristics using SEM, solubility studies, in - vitro dissolution studies, drug content, solvent interactions with DSC, FT - IR, and crystallographic studies by PXRD. The microcrystals produced with Poloxamer 407 showed better dissolution as compared to pure drug and microcrystals formulated using PVP K30. FTIR and DSC results showed that there was no interaction between the drug, solvent and the stabilizer. PXRD of micro - crystals showed higher peak height than pure drug indicating that crystal habit modification occurred in the microcrystals without any polymorphic changes and were found to be smaller in size than pure drug and free from any interactions.
Keywords: Microcrystals, LercanidipineHCl, Poloxamer 407, PVP K 30, methanol
Edition: Volume 12 Issue 7, July 2023,
Pages: 823 - 830