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Research Paper | Surgery | India | Volume 12 Issue 7, July 2023 | Popularity: 5.6 / 10

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Study to Evaluate the Utility of Inflammatory Markers TLC, CRP and Procalcitonin for Staging Acute Cholecystitis in Accordance with Tokyo Guidelines

Dr. Krishna Singh, Dr. Mayank Singh, Dr. Shubham Agarwal

Abstract: Introduction: Acute cholecystitis (AC) is the inflammation of the gallbladder, which develops over hours, usually due to gallstones obstructing the cystic duct. The study aimed to evaluate the utility of inflammatory markers TLC, CRP and procalcitonin for staging acute cholecystitis in accordance with Tokyo guidelines. Methodology: In this prospective observational study, a total of 50patients with right upper quadrant pain were enrolled as per inclusion - exclusion criteria. As per their lipid profile, they were further divided into patients with dyslipidaemia and patients without dyslipidaemia. Along with clinic - demographical data, haemoglobin, platelet count, serum urea, creatinine, LFT, CRP, and PCT were measured. Results: The mean age of patients was 45.34 ? 14.6, with a female dominancy (60.00%). The mean value of Haemoglobin, total leucocyte count and platelet millionsof patientswere 11.73 ? 1.74, 10866.6 ? 5496.98 and 1.84 ? 0.57, respectively. In the present study, 56.00% of study subject's grade of acute cholecystitis was I, followed by II (32%). A significant (mild) positive correlation was seen between total leucocyte count with CRP and procalcitonin. A significant (mild) positive correlation was also seen between CRP with total leucocyte count and procalcitonin. A moderate positive correlation was observed between procalcitonin with total leucocyte count and CRP. Among all the parameters, total leucocyte count was the best predictor of grades I and II while procalcitonin was the best predictor of grade III. Conclusion: According to the results of the present study, TLC, CRP, and PCT can be a predictor in classifying mild/moderate grades of acute cholecystitis. Thus, it can be used as an effective laboratory method in the severity assessment of acute cholecystitis.

Keywords: Gall bladder, Acute cholecystitis, Total Leukocyte Count, C - reactive protein, Procalcitonin

Edition: Volume 12 Issue 7, July 2023

Pages: 1213 - 1220

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