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Case Studies | Nutrition Science | India | Volume 12 Issue 9, September 2023 | Popularity: 4.9 / 10

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Congenital Glucose and Galactose Malabsorption

Sneha Bashaboina

Abstract: Congenital Glucose and Galactose Malabsorption is a rare autosomal recessive disorder. The condition arises due to an impairment in the transport of glucose and galactose across the intestinal lining, which is normally sodium - coupled. From the very first day of life, Congenital Glucose and Galactose Malabsorption manifests as profound diarrhea and dehydration. If lactose (milk sugar), sucrose (table sugar), glucose, and galactose are not eliminated from the diet, CCGM poses a significant risk of causing fatality. In the space enclosed by the small intestine, referred to as the lumen, lactose is typically broken down into glucose and galactose by an enzyme known as lactase. An enzyme known as sucrase breaks down sucrose into glucose and fructose. Subsequently, the protein produced by SGLT1 facilitates the transfer of glucose and galactose from the small intestine's lumen into the cells of the intestine. Usually, the mutations carried by individuals with Congenital Glucose and Galactose Malabsorption result in nonfunctional truncated SGLT1 proteins or in the improper placement of the proteins, preventing them from transporting glucose and galactose out of the intestinal lumen. The untransported glucose and galactose draw water out of the body into the intestinal lumen, resulting in diarrhea.

Keywords: Congenital Glucose, Galactose Malabsorption

Edition: Volume 12 Issue 9, September 2023

Pages: 1788 - 1789

DOI: https://www.doi.org/10.21275/SR23922024258

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