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Analysis Study Research Paper | Nursing | India | Volume 13 Issue 10, October 2024 | Popularity: 7.2 / 10

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A Study to Assess and Compare the Lipid Profile in Critically Ill Patients with Sepsis and without Sepsis

Nisha Singh, Dr. Cimil Babu, Rebika Thongbam

Abstract: Background: Sepsis is a systemic inflammatory disease with high morbidity and mortality caused by a dysregulated host immune response to an infection. There is a significant transition in the distribution of circulating lipoproteins before and after sepsis. Alterations in lipid metabolism and the activation of lipid signaling pathways are components of the complex milieu underlying the pathophysiological sequelae. Lipid mediators play an important role in the proinflammatory and counterregulatory anti - inflammatory changes in the microvasculature in sepsis. Lipids play a critical role in the pathophysiology of sepsis and can impact the outcome of patients with this condition. Materials and methods: In this comparative observation study 100 critically ill patients, 50 each with sepsis and without sepsis were enrolled. From selected patients? socio - demographic variables and clinical parameter were observed; also, Lipid profile was obtained at 24 hours and 72 hours of admission in critical care unit. Result: The findings of the study reveals that there is significant difference between lipid profile of critically ill patients with sepsis and without sepsis (p < 0.05), also there is significant reduction in lipid profile in critically ill patients with sepsis on 24 hours and 72 hours of admission but there were no significant difference observed in lipid profile in critically ill patients without sepsis (p > 0.05) on 24 hours and 72 hours of admission. Conclusion: There is significant difference between lipid profile of critically ill patients with and without sepsis. There is significant reduction in lipid profile in sepsis patients and no significant changes in lipid profile in without sepsis patients.

Keywords: Sepsis, Lipid profile, Patients

Edition: Volume 13 Issue 10, October 2024

Pages: 885 - 890

DOI: https://www.doi.org/10.21275/SR241012125140

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