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Masters Thesis | Medical Science | India | Volume 13 Issue 12, December 2024 | Popularity: 5 / 10

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Diastolic Dysfunction and In - Hospital Mortality in Sepsis: A Study from Tertiary Care Rural Hospital

Dr. Yogesh Khithani, Dr Anjalee Chiwhane, Dr. Anuj Varma, Dr. Sunil Kumar, Dr. Ayesha Ansari

Abstract: Background: Sepsis is a leading cause of mortality with rate eight times more than that due to other causes and is also a major cause of morbidity. Cardiac dysfunction augments the mortality rate in these patients. Diastolic dysfunction can predict long term mortality and morbidity in sepsis and is recognized to be a major cause of heart failure with normal ejection fraction (LVEF>55%). Objectives: Co - relate LVDD with APACHE 2 score and its effect on in - hospital mortality. Methodology: This present study is an observational cross - sectional study from tertiary care rural hospital.140 patients of sepsis were observed for evidence of LVDD. Necessary investigations and cultures were sent. Bedside 2D Echo documented E Wave, A wave and septal e?. Worse APACHE 2 scores during hospital stay were noted. Results: 140 patients of sepsis with mean age is 50.15?16.37 years, 94 (67.14%) were males and 46 (32.86%) females. There were 104 (74.3%) survivors and 36 (25.7%) non - survivors. CKD and DM were important co morbidities.83 patients were culture positive and 88 had positive CRP. Mortality was higher in patients with higher APACHE 2 scores. Presence of LVDD had effect on in - hospital mortality. Conclusions: Mean arterial pressure, positive cultures (from source of infection), APACHE 2 scores and septal e? were strong independent predictors of in - hospital mortality. There is a necessity in monitoring of these parameters to prognosticate in - hospital outcome.

Keywords: Sepsis, Mortality, Left ventricular diastolic dysfunction, Outcome

Edition: Volume 13 Issue 12, December 2024

Pages: 1494 - 1498

DOI: https://www.doi.org/10.21275/SR241222180908

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