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Research Paper | Biochemistry | India | Volume 13 Issue 12, December 2024 | Popularity: 5.2 / 10

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Exploring the Impact of Hypothyroidism on Renal Function: A Comparative Study of Overt and Subclinical Cases

Dr. Bubul Kalita, Dr. Bhawna Bhimte, Dr. Rakesh Singh Jagat, Dr. Tripti Saxena, Dr. Haresingh Makwane

Abstract: Hypothyroidism, a common endocrine disorder characterized by insufficient thyroid hormone production, has wide-ranging systemic effects. While its impact on cardiovascular and musculoskeletal systems is well-documented, the effects on renal function are less understood. Thyroid hormones play a crucial role in kidney development and function, influencing renal blood flow, glomerular filtration rate, and electrolyte homeostasis. This study aimed to assess the impact of hypothyroidism on renal function parameters and compare these effects between overt and subclinical hypothyroidism. Present cross-sectional study was conducted including 150 hypothyroid patients (56 overt, 94 subclinical) at Gandhi Medical College and Hamidia Hospital, Bhopal, over 18 months. Serum creatinine, creatinine clearance, and microalbuminuria were measured alongside thyroid function tests. Present results revealed significantly higher serum creatinine levels and lower creatinine clearance in overt hypothyroidism compared to subclinical hypothyroidism. Microalbuminuria was more prevalent in overt hypothyroidism. The results observed a positive correlation between serum TSH and creatinine, while T4 showed a negative correlation with creatinine. These findings demonstrate a significant impact of hypothyroidism on renal function, with more pronounced effects in overt hypothyroidism. The study suggests that thyroid dysfunction, particularly overt hypothyroidism, is associated with impaired renal function as indicated by increased serum creatinine, decreased creatinine clearance, and a higher prevalence of microalbuminuria. These results underscore the importance of monitoring renal function in hypothyroid patients, especially those with overt disease. Further research is needed to elucidate the mechanisms underlying these thyroid-kidney interactions and to develop targeted strategies for managing renal complications in hypothyroid patients.

Keywords: Hypothyroidism, overt hypothyroidism, subclinical hypothyroidism, thyroid-kidney interaction, renal function, serum creatinine, creatinine clearance, microalbuminuria

Edition: Volume 13 Issue 12, December 2024

Pages: 1762 - 1765

DOI: https://www.doi.org/10.21275/SR241228041815

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