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Case Studies | Medicine | India | Volume 13 Issue 2, February 2024 | Rating: 4.9 / 10

An Intresting Case of Multiple Myeloma Associated Light Chain (AL) Amyloidosis with Renal Involvement Presented as Nephrotic Syndrome

Dr. Umang B. Darji | Dr. Bhratri Bhushan Yadav | Dr. Ravishankar S N

Abstract: Introduction: Multiple myeloma is characterized by the neoplastic proliferation of plasma cells producing a monoclonal immunoglobulin. The plasma cells proliferate in the bone marrow and can result in extensive skeletal destruction with osteolytic lesions, osteopenia, and/or pathologic fractures. In rare cases, patients with multiple myeloma may develop (AL) immunoglobulin light chain amyloidosis as a secondary complication due to abnormal production of immunoglobulin light chains by myeloma cells. Case Report: - We report a rare case of 58-year-old male who presented with anasarca from the previous 2 years and shortness of breath from the last 6 months; at the time of presentation pedal edema and ascites was there, patient has Nephrotic range proteinuria and mild anemia, so we suspected nephrotic syndrome, kidney biopsy was done in suspicious of multiple myeloma, laterkidneybiopsy was suggestive of (AL) immunoglobulin light chain Amyloidosis. Later, a bone marrow biopsy was performed, which was suggested of Multiple myeloma. Further, Patient was given supportive treatment upon admission, followed by Palliative Chemotherapy. Conclusion: Multiple myeloma associated immunoglobulin light chain (AL) Amyloidosis is rare, it can significantly increase patient mortality. Therefore, if AL amyloidosis is suspected in patients with multiple myeloma, assessment of organ involvementand early initiation of intensive care including proper chemotherapy are required.

Keywords: Nephrotic Syndrome, (AL) Immunoglobulin Light Chain Amyloidosis, Multiple Myeloma

Edition: Volume 13 Issue 2, February 2024,

Pages: 1399 - 1402