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Informative Article | Medical Science | India | Volume 13 Issue 3, March 2024 | Popularity: 4.5 / 10
Cachexia: An Unsolved Puzzle
Mohammed Shanil P, Farsana Jasmin K
Abstract: APS type 1 (APS - 1) is a rare, autosomal recessive inherited disorder encompassing chronic mucocutaneous candidiasis, hypoparathyroidism, and autoimmune adrenal insufficiency, with the presence of two of these being essential for diagnosis. APS - 1 primarily affects young patients, both males and females equally. The pathogenesis of the syndrome involves the development of T cells with a high affinity to auto antigens; a defect in the body?s immune system fails to eliminate these T cells, and thus they bind to and attack the host?s cells. Apart from the manifestations listed above, APS - 1 patients can also develop hypogonadism, vitiligo, chronic diarrhea and gastritis, autoimmune hepatitis, autoimmune hypothyroidism, type 1 diabetes mellitus, and pituitary failure.
Keywords: Autoimmune polyglandular syndrome, mucocutaneous candidiasis, T cells, cortisol, adrenal insufficiency
Edition: Volume 13 Issue 3, March 2024
Pages: 223 - 224
DOI: https://www.doi.org/10.21275/SR24304013054
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