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Research Paper | Toxicology Science | India | Volume 13 Issue 3, March 2024 | Rating: 5.1 / 10
Assessment of Toxicity, Genotoxicity and Toxicological Mechanism for Selected Bioactive Compounds Present in Bacopa monnieri Linn. by using ProTox II Webserver
Subrata Ray | Shoumini Chakravarty [2] | Soumendra Nath Talapatra [13]
Abstract: Bacopa monnieri Linn. is commonly known as Bramhi in Bengali and found in marshy area, which is an important medicinal plant as per traditional knowledge. This plant contains several phytochemicals, which are used for anti - Alzheimer?s agent. The present study predicted physico - chemical properties and different types of toxicity parameters viz. acute toxicity (rat oral LD50), hepatotoxicity, immunotoxicity, genotoxicity endpoints viz. cytotoxicity, carcinogenicity, mutagenicity, as well as toxicological mechanism especially stress response pathway of selected phytochemicals of B. monnieri and synthetic medicine (Donepezil) by using ProTox - II webserver. The phytocompounds Memantine and Bacopaside N2 were found class III, categorized as toxic if swallowed. All studied compounds did not show hepatotoxic while 4 phytocompounds Scopoletin, Bacopasaponin G, Bacopaside B and Bacopaside N2 and synthetic medicine viz. Donepezil were obtained immunotoxic active. Regarding genotoxicity, two compounds viz. Bacopaside N2 and Donepezil were found cytotoxic while Scopoletin and Donepezil were obtained carcinogenic, but all compounds were mutagenic inactive. All studied compounds were found inactive for nrf2/ARE, HSE, p53 and ATAD5 while 4 phytocompounds viz. Catechin, Galangin, Bacopasaponin G and Bacopaside N2 were observed MMP active. It is concluded that Bacopasaponin G was found to be better efficacious than Donepezil like drug. In future study, it is suggested to conduct in vivo bioassay to validate these predictive results.
Keywords: Anti - Alzheimer's agent, Bacopa monnieri, Predictive toxicity, In silico, Toxicological mechanism
Edition: Volume 13 Issue 3, March 2024,
Pages: 733 - 736