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Comparative Studies | Obstetrics and Gynecology | India | Volume 13 Issue 3, March 2024 | Popularity: 5.2 / 10
Comparing Efficacy and Safety of Recombinant FSH Originator Product with Biosimilar in Women Undergoing Ovarian Stimulation
Tanya Shubham, Kundavi Shankar, Geetha V. , Rashmi G. V. , Nithya Naaram
Abstract: Background: Biosimilar medications have expanded the treatment possibilities within assisted reproductive technology (ART). Real-world data comparing the clinical outcomes of the original follitropin alfa (Gonal-f?) with its biosimilars are essential for enhancing the existing body of evidence to inform clinical decisions regarding drug selection. Aim of the study was to evaluate the efficacy of biosimilar in comparison to recombinant FSH originator product (Gonal F). Methods: This was a Retrospective Observational Study which involved 220 women who underwent IVF treatment for subfertility from Institute of Reproductive Medicine and Women?s Health, Madras Medical Mission Hospital, Chennai between the year 2020 to 2022. Stimulation outcomes and Reproductive outcomes were analysed in terms of number of days of stimulation, total dose of rFSH used, number of embryos obtained, number of embryos transferred, clinical pregnancy rate, multiple pregnancy rate and miscarriage rate. Results: There was no significant difference in the number of oocytes retrieved, number of M2 oocytes retrieved, number of embryos per cycle and embryos transferred between Biosimilars and Gonal F groups. Reproductive outcomes were similar in terms of clinical pregnancy rate. Conclusion: rFSH Biosimilar is as effective as the originator product and similar safety profile.
Keywords: Assisted reproductive technology, follitropin alfa, gonadotropin?releasing hormone antagonist, infertility
Edition: Volume 13 Issue 3, March 2024
Pages: 759 - 762
DOI: https://www.doi.org/10.21275/SR24310163115
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Obstetrics and Gynecology, India, Volume 9 Issue 3, March 2020
Pages: 1056 - 1058Management of Labour and Obstetric Outcome of Pregnant Women in Latent Phase versus Active Phase of Labour at the Time of Admission
Dr. Jayneel Shah, Dr. Swar Shah, Dr. Kishor Chauhan, Dr. Abhilasha Ramachandran
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Obstetrics and Gynecology, India, Volume 9 Issue 5, May 2020
Pages: 6 - 9A Case of Recurrent Abdominal Pregnancy of Covert Origin
Dr Shikha Sardana, Dr. Rooplekha Chauhan, Dr Anuradha Khanna
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Obstetrics and Gynecology, India, Volume 9 Issue 2, February 2020
Pages: 388 - 390Placental Position and Its Correlation to the Development of Preeclampsia
Vinobha Dondapati, T. Bharathi
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Obstetrics and Gynecology, India, Volume 9 Issue 3, March 2020
Pages: 961 - 963A Study of Palm-Coein Classification of Abnormal Uterine Bleeding & its Clinical-Histopathological Correlation in Perimenopausal Women at Umaid Hospital
Krishna Soni, B.S Jodha
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Obstetrics and Gynecology, India, Volume 9 Issue 2, February 2020
Pages: 333 - 335Role of Increased Hydration in Women in Labor with Unrestricted Oral Intake of Fluids - A Randomised Study
Dr. B. Swetha, Dr. T. Bharathi