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Research Paper | Pathology | India | Volume 13 Issue 5, May 2024 | Rating: 5.4 / 10
Thrombocytopenia in Patients with Sepsis
Dr. Lamia Fatma | Dr. Ambika Agarwal | Dr. Vipin Kathuria | Dr. Prem K. Garg | Dr. Aditi Raina
Abstract: Background: Thrombocytopenia has been observed to be associated with sepsis and present as an early finding in septic patients. Host defense against infection is a product of dual mechanism: the inflammatory response and the activation process of coagulation. The platelets play vital role in both haemostasis and immune response. The above mechanisms work hand in hand in a synchronous and complex manner making the contribution of platelets crucial in sepsis. Aim and Objective: The aim of our study is to show presence of thrombocytopenia in patients with sepsis in various age groups and degree of severity of thrombocytopenia. To establish use of thrombocytopenia as a cost effective and easily available biomarker for early detection of sepsis to reduce mortality. Material and Methods: An observational study was conducted at Department of Pathology, SIMS, Hapur in which a total of 150 patients which were septic (TLC >12, 000/cumm) were included in this study. Results: In our study a total of 150 patients with sepsis (TLC > 12, 000/cumm) and thrombocytopenia were taken into account, in which we observe that 13.33% (n= 20) septic patients have mild thrombocytopenia (platelet count of 1, 00, 00 - 1, 50, 000/ cumm) out of which 6 are female and 15 are male. A total of 76 patients (50.66%) have moderate thrombocytopenia (platelet count of 50, 000 - 99, 000/cumm) out of which 49 are female and 27 are male. When observed, 54 patients with sepsis (36.01%) have severe thrombocytopenia. Out of 54 patients, 42 are female and 12 patients are male.64.66% of patients studied are female.
Keywords: Thrombocytopenia, sepsis, platelet function, Biomarkers, coagulation cascade
Edition: Volume 13 Issue 5, May 2024,
Pages: 30 - 33