International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Review Papers | Biomedical Sciences | Indonesia | Volume 13 Issue 3, March 2024 | Rating: 5.4 / 10


Exploring the Neo-Collagenesis Mechanism of Calcium Hydroxylapatite: A Comprehensive Literature Review

Oktavian Tamon [3]


Abstract: Calcium Hydroxylapatite CaHA has emerged as a pivotal biostimulator filler in aesthetic medicine, renowned for its dual action of immediate soft tissue augmentation and stimulation of collagen production over time. This literature review delves into the neo - collagenesis mechanism of CaHA, exploring its application, effectiveness, and the underlying biological processes. By analyzing various theories and articles, this review illuminates CaHAs role as a minimally invasive dermal filler in combating signs of skin aging and promoting regenerative effects on the skin. The review underscores the necessity for future research, advocating for higher quality clinical studies with larger sample sizes to unravel the intricacies of CaHAs action mechanisms further. This comprehensive insight aims to contribute to the understanding and optimization of CaHA use in regenerative aesthetic treatments, highlighting its significance in halting the aging process through enhanced collagen production and gene expression modulation.


Keywords: Calcium Hydroxylapatite, Dermal Filler, Skin Aging, Aesthetic Medicine


Edition: Volume 13 Issue 3, March 2024,


Pages: 1010 - 1012



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