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Analysis Study Research Paper | General Surgery | India | Volume 13 Issue 3, March 2024 | Popularity: 5.4 / 10

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Hypocholesterolaemia: An Overlooked Risk Factor for Surgical Site Infection

Dr. J. A. Jayalal, Dr. S. Edwin Kins Raj, Dr. P. R. Baghavath, Dr. Dhayanithi E.

Abstract: Background: A surgical site infection (SSI) is an infection that develops in the body where surgery was performed. SSI involves tissues beneath the skin, organs, or implanted materials, or they might be superficial infections affecting simply the skin. After surgery, SSIs are the second most frequent kind of adverse events that hospitalized patients experience. Since cholesterol is the precursor of five major types of steroid hormones, its importance in the human body cannot be understated. In addition to having an impact on immunological response and gluconeogenesis, cholesterol's transport forms, and lipoproteins, also act as carriers of medications, poisons, fat - soluble vitamins, and antioxidants. Therefore, the purpose of the study was to determine whether total cholesterol levels and the incidence of SSI were related. Aims and Objectives: To establish a relationship between hypocholesterolaemia and the occurrence of surgical site infection. Materials and Methods: We prospectively included 60 individuals who were undergoing elective hernia surgery were evaluated for fasting lipid profiles preoperatively and tried to predict the occurrence of SSI during this study. This prospective study was conducted from September 2023 to December 2023 on 60 patients who were admitted and had undergone elective hernia surgeries at Kanyakumari Government Medical College. Results: Out of 60 patients, 11 (18.3%) experienced SSI. Multivariant data analysis revealed several factors were associated with a higher risk of SSI, with hypocholesterolaemia being a significant factor, along with diabetes and hypoalbuminemia. Other factors such as smoking, drinking, gender, and hypertension have no significant influence on the development of SSI in the current investigation, but other factors such as age played a minimal role in raising the incidence of SSI. Conclusion: Hypocholesterolaemia is one of the overlooked characteristics often disregarded but whose consideration can result in a considerable decrease in this preventable consequence.

Keywords: Hypocholesterolaemia, SSI, Hernia, Fasting lipid profile

Edition: Volume 13 Issue 3, March 2024

Pages: 1467 - 1470

DOI: https://www.doi.org/10.21275/SR24321000310

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