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Narrative Review | Medicine | India | Volume 13 Issue 5, May 2024 | Popularity: 4.8 / 10

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A Conspectus Study in Treatment of COVID-19 using Monoclonal Antibodies

R. Kavitha, Lokesh R., Pooja C.

Abstract: To prevent and/or neutralise the coronavirus in infected patients, researchers are rushing to create medicines based on antibodies. The promise for understanding disease pathophysiology was initially provided by the virus's genetic and structural resemblance to the coronavirus associated with severe acute respiratory syndrome (SARS-CoV). Reports of individual monoclonal antibodies against COVID-19 have been published by researchers. The main type of biotherapeutics used in passive immunotherapy to combat viral infection is monoclonal antibodies. In the treatment of numerous diseases, the therapeutic potential of monoclonal antibodies has long been acknowledged. Neutralising monoclonal antibodies prevent the interaction between the viral spike and the ACE 2 receptor, which is present on a variety of cell types, from causing viral infection. The creation of novel monoclonal antibodies treatments for oncology, inflammation, and rare diseases as well as infectious diseases will likely be significantly impacted using the manufacturing, control, and chemistry methodologies because they create a new standard for rapidity, safety, and clinical advantage. Additional investigation into the pathogenesis of COVID-19 may help to pinpoint the best treatment targets for the creation of targeted antivirals to combat this recently discovered disease. This brief review addressed a number of MABs, including an overview of the SARS-CoV-2 immunological response, details on the structure is the spike protein of the SARS-CoV-2 virus, a primary target of the MABs, details on the MABs' mechanisms of action, comparisons to successful vaccines, and an update on the COVID-19 clinical trials using MABs.

Keywords: Monoclonal antibodies, SARS-COV, SARS-COV-2, COVID-19 biotherapy

Edition: Volume 13 Issue 5, May 2024

Pages: 988 - 992

DOI: https://www.doi.org/10.21275/SR24515184940

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