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Research Paper | Biochemistry | India | Volume 13 Issue 5, May 2024 | Rating: 5.3 / 10
Status of Total Antioxidant Capacity in Pre & Post-Menopausal Women with RA
Rajshree Kabra | Dr. Sangita Paneri | Dr. Angoorbala Bafna
Abstract: Introduction: Oxidative stress is a fundamental part of the aging process and outcome of the overproduction of free radicals such as reactive oxygen species (ROS). Usually ROS are neutralized by the antioxidants. Antioxidant levels decreases and brings about the degradation of joint cartilage in patients suffering from Rheumatoid arthritis. A high degree of oxidative stress has been observed in post-menopausal women as well. Aim: To evaluate the status of total Antioxidant capacity in pre and post-menopausal women with and without RA. Material and method: Present study was carried out in MGM Medical College, Indore during March 2023 - October 2023. Total 110 study subjects were taken out of which 35 were control A (Pre-menopausal women) and 35 were control B (Post-menopausal women) & 16 were Case Group A (Pre-menopausal women with RA) and 24 were Case Group B (Post-menopausal women with RA). Blood samples were collected from subjects and analyzed for TAC with kit based method. Inclusion criteria: Medically healthy pre-menopausal women of 20-45 years of age and post-menopausal women of 50-80 years of age and pre-menopausal women with RA of 20-45 years of age and post-menopausal women with RA of 50-80 years of age. Exclusion criteria: RA patients with diabetes, CHD and other major complications. Results: Results reveal that; 1) There are significant decreased levels of TAC has been observed in pre-menopausal and post-menopausal women with RA in comparison to healthy control. 2) There are significant decreased levels of TAC has been observed in post-menopausal women with RA in comparison to pre-menopausal women with RA Conclusion: A remarkable and significant change in the levels of TAC has been observed indicating that post-menopausal women tends to have more oxidative stress as compared to pre-menopausal women in both control as well as case group
Keywords: TAC, RA, Antioxidant
Edition: Volume 13 Issue 5, May 2024,
Pages: 1104 - 1107