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Case Studies | Immunology | India | Volume 13 Issue 5, May 2024 | Popularity: 5 / 10

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Recurrent Pregnancy Loss Linked to Elevated Levels of Perinuclear Anti - Neutrophilic Cytoplasmic Antibodies: A Rare Yet Triumphant Tale!

Dr. Sunil V. Kapur, Dr. Shreya Gowni

Abstract: Recurrent pregnancy loss (RPL) and autoimmunity are known to be associated. In many instances of RPL, there is a failure in normal control mechanisms that prevent an immune reaction against self, resulting in an autoimmune response. Autoantibodies to phospholipids, thyroid antigens, nuclear antigens and others have been investigated as possible causes for RPL. We report a rare instance of RPL linked to severe immunological thrombocytopenia, chronic high - titer positivity for perinuclear antineutrophilic cytoplasmic antibodies (pANCA), hypertension, diabetes (Type 1), and negative antinuclear antibodies (ANA), Antiphospholipid antibodies (APLA) and anti - dsDNA antibodies. In our case, all three cases of pregnancies resulted in fetal death, despite the fact that our patient features did not fit any serological and clinical manifestations/criteria of any systemic autoimmune (vasculitic or non - vasculitic) disease except that her p - ANCA titers remained elevated. She successfully delivered a healthy baby when she was put on immunosuppression throughout her fourth pregnancy despite persistent high titer - pANCA levels.

Keywords: Recurrent pregnancy loss, pANCA, auto - immunity

Edition: Volume 13 Issue 5, May 2024

Pages: 1127 - 1128

DOI: https://www.doi.org/10.21275/SR24517092305

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