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Research Paper | Pathology | India | Volume 13 Issue 5, May 2024 | Popularity: 5.4 / 10

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Histomorphometric Characterization of Oral Potentially Malignant Disorders and OSCC: New Age Perspective

Chhavi Saigal, Shruti, Dinabati Huidrom, Saurabh Juneja, Ankita Khare

Abstract: Introduction: Early detection of potentially malignant lesions is the most crucial determinant for successful treatment, better prognosis, and survival. Computerized image analysis (CIA) based assessment of immunostaining pattern enables objective interpretation and quantification for differential diagnosis of the state of pathology elucidated by the tissue being investigated, to investigate the cellular and the nuclear changes in correlation with the histological behavior of the lesions. The quantitative and qualitative analysis of several parameters may reveal incipient cellular changes and thus offer high reliability over routine histopathological examination. Aim and Objectives: Our present study was undertaken to assess, analyze and compare the morphometric parameters with the changes occurring in epithelial cells of OPMDs and OSCC. Materials and Methods: 20 cases were obtained and stained with hematoxylin and eosin. The sections were subjected to morphometric analysis to analyze all the morphometric parameters in OPMDs and OSCC using various image analyzer softwares (FIJI). Result: Quantification of cells gave accreditation for identification of cell layers. Morphometric parameters showed significant variations to differentiate grades of dysplasia and sites of oral epithelium. Conclusion: The simple, inexpensive and easy morphometric analysis method can make the histomorphological study of tissues with premalignant lesions a more objective and practically applicable one for the early detection of cancer.

Keywords: Morphometry. Dysplasia, Oral squamous cell carcinoma, OSMF

Edition: Volume 13 Issue 5, May 2024

Pages: 1343 - 1347

DOI: https://www.doi.org/10.21275/SR24521093856

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