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Subjective Paper | Medicine | India | Volume 13 Issue 5, May 2024 | Popularity: 4.8 / 10

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A Rare Encounter: Microangiopathic Hemolytic Anemia - A Case Report

Dr. S. Adhitya Surya

Abstract: Microangiopathic hemolytic anemia (MAHA) is a multifaceted hematological disorder characterized by the fragmentation of red blood cells due to their passage through damaged small blood vessels. This case report delves into a compelling instance of MAHA in a 42 - year - old female patient with no prior history of hematological abnormalities. The patient presented with a constellation of symptoms, including fatigue, jaundice, and dark urine, prompting a thorough diagnostic investigation. Detailed clinical assessments, laboratory analyses, and imaging studies were conducted, revealing the presence of schistocytes on peripheral blood smear, anemia, thrombocytopenia, elevated lactate dehydrogenase levels, and decreased haptoglobin levels. Additional testing uncovered a positive Coombs test, ruling out immune - mediated hemolysis. Based on these findings, a diagnosis of MAHA was established. Further exploration of potential underlying etiologies, such as thrombotic microangiopathy (TMA) and associated conditions, including atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP), was undertaken. Comprehensive treatment strategies, including plasmapheresis and immunosuppressive therapy, were initiated to manage the patient?s severe clinical presentation. This case report highlights the diagnostic challenges, therapeutic considerations, and clinical outcomes in managing MAHA, emphasizing the importance of a multidisciplinary approach to address this rare hematological disorder effectively. It underscores the need for continued research and awareness of MAHA to improve patient care and outcomes.

Keywords: microangiopathic hemolytic anemia, von willebrand, ADAMTS13, Schistiocytes

Edition: Volume 13 Issue 5, May 2024

Pages: 1582 - 1585

DOI: https://www.doi.org/10.21275/SR24524062148

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