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Analysis Study Research Paper | Medical Microbiology | India | Volume 13 Issue 6, June 2024 | Rating: 4.6 / 10
Microbial Profile of Corneal Scrapping Samples Received in Department of Microbiology in a Tertiary Care Hospital, Himachal Pradesh
Dr. Manvi Sharma | Dr. Dogra Kumari Deeksha | Dr. Rana Aditya | Dr. Sood Anuradha C | Dr. Kaur Isampreet
Abstract: Corneal diseases are the major cause of blindness in developing countries. Keratitis defined as inflammation of cornea, which can be of infectious or non - infectious etiology. Bacteria, fungi, viruses or parasites all can cause infectious keratitis, and in developing countries bacterial and fungal etiology is more common. A hospital based retrospective analysis of microbiological profile and antibiotic resistance pattern of all corneal scrapping samples received in Department of Microbiology, Tanda was done for a period of 2 years, i. e. from April 2022 to April 2024. Out of total 52 samples received, total of 13 (25%) samples were culture positive. Out of 13 samples, 9 (17.31%) samples showed bacterial growth, 4 (7.69%) samples were positive for fungal etiology. Out of 9 positive samples for bacterial isolates, 3 samples showed growth of Staphylococcus aureus, 3 Pseudomonas species, 1 Escherichia coli, 1 Enterobacter species and 1 of Acinetobacter species. Out of 4 positive samples for fungal etiology, 2 showed growth of Fusarium species, 1 Aspergillus flavus and 1 Penicillium species. In gram positive bacterial isolates, Doxycycline (100%), Vancomycin (100%) and Linezolid (100%) were the most sensitive drugs followed by Cotrimoxazole (66.67%) and Levofloxacin (66.67%). In Non - Lactose Fermenting bacteria (NLF), Doripenem (100%) and Colistin (10%) were the most sensitive drugs followed by Ceftazidime (50%) and Cefepime (50%). In Enterobacteriaceae, only Ampicillin - Sulbactam (50%) showed resistance.
Keywords: corneal diseases, keratitis, microbiological profile, antibiotic resistance, developing countries
Edition: Volume 13 Issue 6, June 2024,
Pages: 680 - 683