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Review Papers | Dermatology | Indonesia | Volume 13 Issue 6, June 2024 | Rating: 5.3 / 10
The Role of Exosome Intradermal Injection in Stimulating Neocollagenesis: A Systematic Literature Review
Abstract: The aim of this research is to investigate the potential of exosomes in promoting the synthesis of new collagen in the skin, specifically focusing on their applications in anti - aging therapy. This study adopts a systematic review approach to gather and analyze data from various studies that examine the effects of intradermal exosome injections on neocollagenesis. Exosomes, nano - sized vesicles released from various types of cells, including stem cells, are known to play a role in intercellular communication and are involved in numerous biological processes, including tissue repair and modulation of the immune system. The research results indicate that the most commonly used method is a review. The primary factors stimulating neocollagenesis include dermal remodeling, activation of the TGF - ?/Smad pathway, mRNA, the use of Calcium Hydroxyapatite (CaHA), TGF - ?, regulation of TNF - ?, MMP - 1 inhibition, anti - inflammatory effects, reduction of oxidative stress, the use of exosomes derived from placental mesenchymal stem cells, high - intensity LED therapy, the use of fillers containing EGF (Epidermal Growth Factor), exosomes from Mesenchymal Stem Cells (MSCs), and UVB. The role of intradermal exosome injections in stimulating neocollagenesis is to treat photoaged skin.
Keywords: exosomes, collagen synthesis, anti - aging therapy, skin rejuvenation, intradermal injections
Edition: Volume 13 Issue 6, June 2024,
Pages: 1381 - 1386