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Case Studies | Pediatrics | Colombia | Volume 13 Issue 6, June 2024 | Rating: 4.9 / 10

Pulmonary Hypertension in the Newborn: More Than Persistent Hypoxemia: Case Report and Literature Review

Valeria Pumarejomuoz | Paula Herrera Revollo | Jhan Bastos Mendoza | Mara Fernanda Becerra | Oscar Osorio Carbon | Maristella Ayala

Abstract: Persistent pulmonary hypertension of the newborn is a clinical condition with a low global incidence (2 to 4 per 1000 live births), predominant in premature and post-term infants, yet with significant mortality (up to 33%). The comprehensive management of this syndrome, characterized by persistent and severe hypoxemia due to failure in fetal circulation transitioning to extrauterine life, poses a real challenge in low and middle-income countries. This is primarily due to limited availability and high costs of first-line therapies such as nitric oxide once the diagnosis is established. We present a case from a referral institution in Barranquilla, Colombia, of a 32-week male newborn with early neonatal sepsis, hyaline membrane disease, and marked clinical deterioration, diagnosed with pulmonary hypertension by echocardiography. He was managed with nitric oxide and simultaneous high-frequency mechanical ventilation for 24 hours, showing an adequate response. Additionally, a phosphodiesterase type 5 inhibitor and inodilator were adjunctively administered, resulting in subsequent reduction and normalization of pulmonary pressure.

Keywords: Pulmonary hypertension, fetal circulation, newborn, nitric oxide, mechanical ventilation

Edition: Volume 13 Issue 6, June 2024,

Pages: 1705 - 1709