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Research Paper | Surgery | India | Volume 13 Issue 7, July 2024 | Rating: 5.8 / 10
An Ambispective Observational Study to Assess the Association of Clinicomicrobiological Profile with Outcome in Diabetic Foot Ulcers in a Tertiary Care Setup
Dr. Trivarna Dey, Dr. Manjunath B. D., Dr. Niyaz Ahmed
Abstract: Background: Diabetes is a dynamic, long term metabolic disorder and affects an estimated 537 million people worldwide which accounts to 10.5% of all adults in the age range of 20 to 80 years. About one in four diabetic patients tend to develop a foot ulcer during their lifetime. It has been observed that 80% of amputation in diabetic patients are preceded by a diabetic foot ulcer. The present study was undertaken to assess any association between type of microorganism and foot ulcers leading to amputations along with change in microbial culture and antibiotic sensitivity. Materials and methods: This study is an ambispective observational study which has been conducted at department of general surgery, Bangalore Medical College and Research Institute from March 2022 to March 2024 on 165 patients having diabetic foot ulcer. The study was divided into two groups, one included retrospective chart review from march 2022 to July 2023 and other prospective follow up from July 2023 to march 2024. Results: In initial 12 months of period based on MAC of antibiotics most sensitive antibiotic was found to be piperacillin - tazobactam and imipenems. In following period, majority of isolates were resistant to carbapenams and piperacillin tazobactam. And was found to be sensitive mostly to tigecycline, linezolid. Also, pseudomonas was isolated more in patients with prolonged morbidity and death in the initial period which was significant, and a shift to Acinetobacter was seen in the following period. Conclusions: Hence, a periodic basis wound swabs should be sent for culture and antibiotic sensitivity, so that antibiotic protocol and organism can be monitored and a better treatment protocol can be derived periodically to decrease the morbidity and mortality in diabetic foot ulcers.
Keywords: diabetic foot ulcer, amputation, culture, antibiotic sensitivity, morbidity, mortality
Edition: Volume 13 Issue 7, July 2024
Pages: 77 - 82