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Research Paper | Medicine | India | Volume 13 Issue 8, August 2024 | Rating: 3.9 / 10
Sickle Cell Disorder: Unraveling the Diverse Clinical Presentations
Dr. Y Veda Parimala | Dr. D Ravi Teja
Abstract: This study investigates the clinical presentations of sickle cell disorders (SCD) among patients admitted to the General Medicine department at Mallareddy Institute of Medical Sciences. The research encompasses a cross - sectional hospital - based study involving ten patients, aged 15 to 49, diagnosed with sickle cell disease (SCD) through hemoglobin electrophoresis. The study reveals diverse clinical manifestations, with 70% of patients being male and 50% aged between 21 - 30 years. Among the participants, 80% were homozygous (HbSS) while 20% were heterozygous for SCD. The hemoglobin levels varied, with 33% having Hb <6.5 gm/dl, and 40% in the 6.5 - 10 gm/dl range. Clinical symptoms ranged from asymptomatic cases to severe conditions such as recurrent infections, leg ulcers, acute chest syndrome, avascular necrosis, and osteomyelitis. The findings highlight the varied severity and presentation of SCD, emphasizing the need for targeted medical interventions and continuous monitoring to manage this genetic disorder effectively. The study aligns with previous research, suggesting a higher prevalence of complications among male patients and the need for comprehensive care strategies.
Keywords: sickle cell disorder, hemoglobinopathies, clinical features, anemia, patient study
Edition: Volume 13 Issue 8, August 2024,
Pages: 305 - 307