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Narrative Review | Medicine | India | Volume 13 Issue 7, July 2024 | Popularity: 5.4 / 10

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A Review of Efonidipine vs Amlodipine for Hypertension Management: Evaluating Efficacy, Safety and Additional Therapeutic Benefits

Dr. Rahul Garg

Abstract: Background: Calcium channel blockers (CCBs) like amlodipine are widely prescribed for hypertension management. However, efonidipine, a newer dual L - type and T - type CCB, may offer advantages over amlodipine. Objective: To evaluate the efficacy, side effect profiles, and additional therapeutic benefits of efonidipine compared to amlodipine for hypertension treatment. Methods: A review of clinical studies comparing efonidipine and amlodipine in patients with mild to moderate hypertension was conducted. Data on blood pressure reduction, adverse effects (peripheral edema, reflex tachycardia), and additional therapeutic properties were analyzed. Results: Evidence suggests efonidipine is equally effective as amlodipine in reducing blood pressure. Notably, efonidipine exhibits a lower propensity for causing peripheral edema and reflex tachycardia compared to amlodipine. Additionally, efonidipine has demonstrated potential renoprotective, cerebroprotective, and anti - inflammatory effects. Conclusions: Efonidipine may be a superior alternative to amlodipine for hypertension management due to its comparable efficacy, more favorable side effect profile, and added therapeutic benefits. Its unique dual mechanism of action targeting both L - type and T - type calcium channels makes efonidipine a promising option, particularly for patients experiencing adverse effects with other CCBs. However, more long - term studies are needed to further establish its clinical implications.

Keywords: Efonidipine, Amlodipine, Hypertension, Calcium Channel Blockers, Peripheral Edema, Reflex Tachycardia

Edition: Volume 13 Issue 7, July 2024

Pages: 786 - 788

DOI: https://www.doi.org/10.21275/SR24714113108

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