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Research Paper | Ophthalmology | Iraq | Volume 13 Issue 7, July 2024 | Popularity: 5.2 / 10

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Inflammatory Biomarkers by Swept Source Optical Coherence Tomography in Diabetic Maculopathy

Mohammad Asaad Abbas, Zaid Rajab Hussein, Ali Mohammed Abdulsahib

Abstract: Aims: To assess the prevalence of inflammatory markers in diabetic patients with macular edema and to assess some factors related to it. Patients and methods: This is a cross - section study enrolled patients with diabetic maculopathy, the study was carried out at Jenna Ophthalmic Center in Baghdad between February 2023 and April 2023 including diabetic patients type 2 with diabetic macular edema with no history of previous intravitreal injections or laser therapy. All patients were examined by swept - source optical coherence tomography (OCT) to examine for inflammatory and other biomarkers. Results: This study enrolled 81 diabetic patients, with a mean age of 56.53? 8.18 years, 42 (51.9%) signs of inflammation on OCT. The inflammatory biomarkers that were identified included 12/42 (28.6%) with hyper - reflective foci (HRF), 36/42 (85.7%) with subretinal fluid (SRF). There was a statistically significant difference in central macular thickness between cases with positive HRF?SRF and negative HRF?SRF, as the CMT was 427.1?100.67 ?m in negative cases while it was 510.26?123.66 ?m in positive cases (P - value =0.001). Conclusion: Inflammatory biomarkers on OCT should not be ignored anymore, and central macular thickness should not be the sole factor that is depended on during follow - up.

Keywords: inflammatory markers, diabetic macular edema, diabetic maculopathy, diabetic patients, optical coherence tomography, central macular thickness

Edition: Volume 13 Issue 7, July 2024

Pages: 1063 - 1066

DOI: https://www.doi.org/10.21275/SR24721135552

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