Downloads: 3 | Views: 42 | Weekly Hits: ⮙4 | Monthly Hits: ⮙4
Research Paper | Medical Science | India | Volume 13 Issue 8, August 2024 | Rating: 5.6 / 10
Study of Thyroid Profile in Diabetic Versus Non - Diabetic Chronic Kidney Disease Patients
Dr. Shruti R. Shinde, Dr. Avinash Chaudhari, Dr. Amar Kulkarni
Abstract: Objectives: Chronic kidney disease (CKD) and its progression is associated with a number of complications, including thyroid dysfunction, in particular hypothyroidism. The objective of the study was to compared the thyroid profiles in diabetic and non - diabetic chronic kidney disease. Also, thyroid profiles were compared in different stages of CKD and in dialyzed versus non - dialyzed patients. Methods: An observational study was conducted among 150 CKD patients at DY Patil Hospital, Nerul.75 of the patients were of diabetic kidney disease. Demographic features, medical history of diabetes mellitus, hypertension and renal disease of each patient were noted, and blood samples were analyzed for free triiodothyronine (T3), free thyroxine (T4), thyroid stimulating hormone (TSH). Results: Thyroid dysfunction was found in 48.7 % CKD patients, the most common was subclinical hypothyroidism (45.3%). When compared to non - diabetic chronic kidney disease patients, diabetic kidney disease patients had higher prevalence of subclinical hypothyroidism (32% vs 58.6%). Stage 4 and 5 CKD patients had higher prevalence of having subclinical hypothyroidism as compared to stage 3 patients (54.1% vs 48.9% vs 30.5% respectively). Subclinical hypothyroidism was found to be more in patients undergoing hemodialysis as compared to those not under hemodialysis (61.5% vs 32.65%). Conclusions: CKD patients of diabetic origin were more prone to thyroid abnormalities as compared to CKD patients of non - diabetic origin. Stage 4 and 5 CKD patients had significantly higher risk of having thyroid dysfunction as compared to stage 3 patients. Thyroid dysfunction was found to be more in patients undergoing hemodialysis as compared to those not under hemodialysis.
Keywords: Chronic kidney disease, diabetic kidney disease, Subclinical hypothyroidism, Thyroid dysfunction
Edition: Volume 13 Issue 8, August 2024
Pages: 1517 - 1522