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Research Paper | Dentistry | India | Volume 13 Issue 9, September 2024 | Popularity: 5.8 / 10

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A Comparative Evaluation of Clinical Effectiveness of Platelet Rich Fibrin and Bone Graft in the Management of Intrabony Defects: Clinico - Radiographic Study

Neelam Thapa, Chander Shekhar Joshi, Pradeep Shukla, Mona Dagar, Rashmi Siwach, Narayan R. R., Yusra Aamir

Abstract: Introduction: Periodontitis, an inflammatory disease, causes tooth support loss primarily due to periodontal ligament fiber and bone loss, resulting in periodontal endosseous defects. Demineralized bone matrix (DBM), known for its osteoinductive properties, is widely used. Combining PRF with bone grafts shows promising result in enhancing wound healing and bone regeneration, especially in intrabony defects, warranting further research for comprehensive efficacy assessment. Aim & Objectives: The aim of this study is to assess the efficacy of combining autologous platelet - rich fibrin (PRF) with bone graft (DBM) in treating three - wall intrabony osseous defects, in comparison with PRF alone. Methodology: The data for this study were sourced from outpatient Department of Periodontology and Implantology at D. J. College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India. A total of 45 participants were randomly assigned to three groups: PRF alone, PRF + DBM, and Open Flap Debridement (OFD), with sufficient sample size justified for power analysis. The study beholden inclusion and exclusion criteria followed a prospective, randomized clinical trial design, involving detailed pre - treatment assessments, surgical interventions, and postoperative evaluations at 6 and 9 months. Result: Group II (PRF + DBM) showed superior outcomes in probing depth reduction, clinical attachment level (CAL) gain, width of keratinized gingiva, and radiographic bone defect reduction compared to PRF alone (Group I) and OFD (Group III). Statistical analyses confirmed the synergistic effect of PRF and DBM, suggesting their potential for enhancing periodontal regeneration. Conclusion: The study demonstrated that PRF combined with DBM improved clinical and radiographic parameters compared to PRF alone in intrabony defect. Addition of DBM change the effect of PRF in CAL gain and radiographic defect fill.

Keywords: PRF, bone graft, intrabony defect, periodontal regeneration, demineralized bone matrix

Edition: Volume 13 Issue 9, September 2024

Pages: 1063 - 1069

DOI: https://www.doi.org/10.21275/SR24918193319

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