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Review Papers | Biotechnology | India | Volume 13 Issue 9, September 2024 | Popularity: 6.1 / 10
Isolation of L-Asparaginase Enzyme from Microbes
Abhishek Ashok Nagergoje
Abstract: L-Asparaginase (EC 3.5.1.1) is a crucial enzyme with significant therapeutic applications, especially in the treatment of acute lymphoblastic leukemia (ALL). It catalyzes the hydrolysis of L-asparagine into L-aspartate and ammonia, thus depleting the supply of asparagine, which is essential for the survival of certain tumor cells. L-Asparaginase is produced by various microorganisms, including bacteria, fungi, and actinomycetes. The microbial production of this enzyme has drawn attention due to its cost-effectiveness, ease of fermentation, and ability to produce high yields. This review article focuses on the microbial sources of L-Asparaginase, methods of isolation and purification, and the importance of optimizing the production conditions for industrial and therapeutic applications.
Keywords: L-Asparaginase, e-coli, Aspartic acid
Edition: Volume 13 Issue 9, September 2024
Pages: 1576 - 1577
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