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Research Paper | Biochemistry | India | Volume 13 Issue 9, September 2024 | Popularity: 4.9 / 10
Prediction of Site Directed Mutagenesis of Acetylcholinesterase by Using Hotspot Wizard Tool
Kallol Sil, Soumendra Nath Talapatra
Abstract: The present study was predicted mutability position of acetylcholinesterase (PDB ID: 2X8B) by using an online academic tool (HotSpot Wizard, version 3.1). The prediction results were obtained through an output interface in which the functional hotspot of acetylcholinesterase indicated only chain A attached to residues like Glu at 202, Ala at 204 position and Ser at 125 positions, respectively. The pockets were obtained in 1 (catalytic) for all residues in which B - factor values 61.86, 59.91 and 52.35 ?2, respectively. There was predicted higher mutability rate with the score value of 6 in the same chain A. It is concluded that this predictive study is beneficial to detect antidotes related to the specific protein.
Keywords: Acetylcholinesterase, Bioinformatics, Protein engineering, HotSpot Wizard, Mutability position
Edition: Volume 13 Issue 9, September 2024
Pages: 1597 - 1600
DOI: https://www.doi.org/10.21275/SR24926121958
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