Downloads: 107 | Views: 299
Research Paper | Medicine Science | India | Volume 4 Issue 4, April 2015 | Popularity: 6.7 / 10
A Prospective Comparison of the Ondansetron Plus Aprepitant, Versus Ondansetron for the Prevention of Chemotherapy Induced Nausea and Vomiting
T. Siva Rama Krishna, G. Lakshmi Durga, Pamidi. Pradeep, P. Chandra Sai
Abstract: OBJECTIVE The objective of study is to compare Ondansetron plus Aprepitant versus Ondansetron-s safety for the prevention of chemotherapy induced nausea and vomiting in patients receiving Cisplatin and 5-Fluorouracil as their treatment for managing cervix cancer and head and neck cancer. METHODS The study was conducted in a Radiotherapy Department of tertiary care teaching hospital. Patients with cervix cancer and head and neck cancer who were scheduled to receive treatment with cisplatin and 5-fluorouracil were randomized to receive 1 of 2 treatment regimens, the standard therapy group received intravenous ondansetron 8 mg and intravenous dexamethasone 4 mg on Days 1-3. The aprepitant group received oral aprepitant 125 mg, intravenous ondansetron 8 mg, and oral dexamethasone 4 mg on Day 1, oral aprepitant 80 mg and oral dexamethasone 8 mg once daily on Days 2-3. RESULTS Of the 86 patients screened 82 were randomized. Twenty-seven (75 %) of 36 patients achieved a CR in the acute phase (days 1 through 5) on the aprepitant cycle, and fourteen (32.5 %) of 43patients had a CR on the placebo cycle. In the delayed phase (days 6 through 8), 23 (64 %) of the patients on the aprepitant cycle had a CR, and 21 (48.8 %) of the patients on the placebo cycle achieved CR. The overall number of patients with CR for days 1through 8 was 19 (52.7 %) on the aprepitant cycle compared with 12 (27.9 %) on the placebo cycle. CONCLUSION There was a significant improvement in complete response rate with aprepitant combined with a 5HT3-RA and dexamethasone as on par with 5HT3-RA and dexamethasone alone.
Keywords: Aprepitant, Ondansetron, chemotherapy, nausea and vomiting
Edition: Volume 4 Issue 4, April 2015
Pages: 2193 - 2195
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 0
Research Paper, Medicine Science, Indonesia, Volume 11 Issue 5, May 2022
Pages: 800 - 803EGFR and KRAS Oncogene Expressions Among Lung Cancer Patients in North Sumatera
Fannie Rizki Ananda, Noni Novisari Soeroso, Setia Putra Tarigan, Erna Mutiara
Downloads: 105
Research Paper, Medicine Science, India, Volume 4 Issue 2, February 2015
Pages: 1184 - 1191A Randomized Controlled Study on Effect of Intravenous Paracetamol as a Pre-Emptive Analgesic In Patients Undergoing Hysterectomy
Dr. Prutvi Shetty MBBS, Dr. Naseema V. Kanase MBBS DA M D. Anaes, Dr. V. K. Dhulkhed. M D Anaes, Sandhya Jagadale Msc. N, Kavita Kapurkar Msc. N
Downloads: 108
Case Studies, Medicine Science, India, Volume 3 Issue 10, October 2014
Pages: 1051 - 1053Unusual Presentation of a Rare Soft Tissue Neoplasm; Myofibroma of the Ear
Dr. Abhilasha Asthana, Dr. Amit Kumar Singh
Downloads: 110
Dissertation Chapters, Medicine Science, India, Volume 3 Issue 12, December 2014
Pages: 1078 - 1082A Comparison between Intracavitary Brachytherapy and Interstitial Brachytherapy in Carcinoma Cervix (Stage IIB and Stage IIIB) - Prospective Randomized Study
Sridhar.P, Thejaswini.B, Giri.G.V, Nanda.R
Downloads: 110
Research Paper, Medicine Science, India, Volume 5 Issue 9, September 2016
Pages: 975 - 979Comparison of 99M Technetium Sestamibi Brain Single Photon Emission Computed Tomography (SPECT) with Computed Tomography (CT) & Magnetic Resonance Imaging (MRI) in Differentiating Tumor Recurrence From Radiation Necrosis in Post Therapeutic Gliomas
Santhi Bhushan Murari, Ranadheer Gupta Manthri, Tejonath Gadepalli, Manas Panigrahi, Prabhaker Rao VVS