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Review Papers | Hematology | India | Volume 4 Issue 4, April 2015 | Popularity: 6.9 / 10

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Platelet Count and Mean Platelet Volume- key hematological Indices in Determination of Various Clinical Perspectives- A Review

Nasreen Sultan, S K Sharma

Abstract: The key role of Platelet is well known and studied in both physiological and clinical point of view in presumption of numerous aberrances. Moreover, it is the most indispensable and constitutional component of blood whose participation and activity is needed for the normal regulation of human physiology. The building mechanism of haemostatic plug at the site of injury is a quite interesting phenomenon, executed by these small platelets to stop blood shedding. Considering this event of bleeding arrestment, several works have been put forwarded to demonstrate the role of platelets and platelet related parameters. This review focuses on Platelet count and Mean Platelet Volume (MPV), which are found to be the most significant and extraordinary components of blood in assumption of various atypical facets interlinked with these hematological indices. A number of platelet defects have been recognized by many researchers to expose the various atherosclerotic complications, arises due to increased platelet activity. Instead, the size and morphology of platelet, the receptors provided on its surface unlocks many mysteries behind the diseases that can be categorizes as, immune deficiencies, inborn and acquired anomalies. Hence, it provides an obvious identification in correlating both the genotypic and phenotypic constitutions of an individual, associated with variable bleeding abnormalities. Platelet deformities also exists heterogenetically in some other diseased conditions like Beta-thalassemia and sickle cell anemia. These are the most common hemoglobinopathies prevailed in northeast India due to its diversified ethnic horizon. This in turn amplifies the bleeding manifestations and resulting into extreme critical events for survival. Therefore, any qualitative or quantitative etiologies behind platelet defects require deep analysis and investigation to discover the various responsible upshots.

Keywords: Platelet, Mean Platelet Volume, Hemoglobinopathies, Thalassemia, Atherosclerosis

Edition: Volume 4 Issue 4, April 2015

Pages: 3347 - 3350

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