Downloads: 119 | Views: 254
Research Paper | Chemistry | India | Volume 4 Issue 8, August 2015 | Popularity: 6.4 / 10
Determination of Candesartan Cilexetil in Bulk and Pharmaceutical Dosage Forms by Visible Spectrophotometric Methods
Ch. Muralikrishna, C. Rambabu
Abstract: Two new rapid, simple, sensitive reproducible and economical spectrophotometric methods are described for the determination of Candesartan cilexetil (CDC) in bulk form. Both methods are based on the formation of colored complexes due to the action of 2, 6-Dichloroquinone chlorimide (DCQC) and 1, 2 Napthaquinone, 4- Sulphonic acid (NQS) on CDC in alcoholic medium. Under optimized conditions, they show an absorption maxima at550 nm (DCQC) and 480nm (NQS), with molar absorptivities of 1.237 x 104 and 3.366 x 104 mole- cm- and sand ells sensitivities of 0.06329 and 0.1578 per 0.001 absorbance unit for DCQC and NQS, respectively. The color is stable for 5 min after extraction. Beers law is obeyed between 5.0-25.0 g/ ml for DCQC and 4.0-20 g/ ml for NQS. The proposed methods were successfully extended to bulk and Pharmaceutical dosage forms.
Keywords: Candesartan cilexetil CDC, 2, 6-Dichloroquinone chlorimide DCQC, 1, 2 Napthaquinone, 4- Sulphonic acid NQS, Spectrophotometry, Oxidative coupling
Edition: Volume 4 Issue 8, August 2015
Pages: 492 - 495
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 53
Research Paper, Chemistry, Nigeria, Volume 2 Issue 3, March 2013
Pages: 457 - 459Selenium Content in some Brands of Bottled Beer Marketed in Makurdi Town Benue State, Nigeria
A. D. Oklo, R. Sha'Ato, K. Asemave, C.Mkurzurum
Downloads: 131 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Chemistry, India, Volume 5 Issue 5, May 2016
Pages: 2066 - 2070Comparative Study of the Antiurolithiatic Activity of Plant Hydroalcoholic Extract of Argemone mexicana, Cissus javana DC and Garcinia pendunculata
O. Ibopishak Singh, A. Bimola Devi
Downloads: 158 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Chemistry, Iraq, Volume 7 Issue 8, August 2018
Pages: 39 - 43p-Aminobenzoic Acid as a New Reagent in Spectrophotometric Determination of Salbutamol Sulphate Via Oxidative Coupling Reaction
Nabeel S. Othman Ali M. Asaad
Downloads: 129 | Monthly Hits: ⮙2
Research Paper, Chemistry, Nigeria, Volume 2 Issue 4, April 2013
Pages: 463 - 467Heavy Metal Analysis of Blends of Methyl Esters Obtained from Four Virgin Tropical Seed Oils
O. G. Igbum, K. Asemave, C. A Nwadinigwe, N. Y. Akaasah
Downloads: 125
Research Paper, Chemistry, United Kingdom, Volume 4 Issue 1, January 2015
Pages: 1527 - 1529Antibacterial Studies of Leucine Complexes of Fe (III) and Cu (II)
K. Asemave, B. A. Anhwange, T. J. Anom