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Research Paper | Biology | India | Volume 4 Issue 8, August 2015 | Rating: 6.1 / 10

Isolation of m-RNA from the Blood Samples of Neonatal Jaundice Patients and then Studied the Expression of Glucose 6-Phosphate Dehydrogenase (G6PD) Gene through cDNA Synthesis and Amplification

Sizu Mittal | Meenakshi Kalia

Abstract: Diseases can be caused either due to genetic factors or physiological factors. But, there are some diseases which can occur due to both of these affects e. g. neonatal jaundice. Main characteristics of the disease are hyperbilirubinemia and yellowing of the skin of patient. Genes play important role in causing the disease which control the enzymes that are responsible in bilirubin excretion process, and epigenetic factors are also responsible which regulate transcription of these genes. One enzyme that we studied was glucose 6-phosphate dehydrogenase which is responsible in causing neonatal jaundice. So, to study the role of epigenetic factors in glucose 6-phosphate dehydrogenase deregulation in neonatal jaundice patients present work was performed

Keywords: Hyperbilirubinemia, epigenetic factors, neonatal jaundice and, glucose 6-phosphate dehydrogenase G6PD gene, malaria

Edition: Volume 4 Issue 8, August 2015,

Pages: 1250 - 1252