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Research Paper | Chemistry | Iraq | Volume 4 Issue 9, September 2015 | Popularity: 6.6 / 10
Synthesis and Biological Evaluation of a mutual Prodrug of Mafenide and Nalidixic Acid by Amino Acid Spacer
Enas Sami Ali, Ahlam J. Qasir
Abstract: The aim of this study has been to synthesize a useful drug, which may act with effectiveness both on the gram-positive and gram-negative bacteria (broad-spectrum). An amide-based mutual pro drugs were synthesized by coupling Mafenide acetate with Nalidixic acid by amino acid spacer (glycine or phenylalanine), and evaluated for in-vitro antibacterial activity with significant results.
Keywords: Nalidixic acid, Mafenide acetate, Pro drug, Antibacterial, glycine and phenylalanine
Edition: Volume 4 Issue 9, September 2015
Pages: 992 - 995
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