International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 126 | Views: 281

Research Paper | Chemistry | India | Volume 4 Issue 1, January 2015 | Popularity: 6.8 / 10


     

Synthesis, Characterization and Evaluation of Antimicrobial Activity of Various Mannich Bases of Isoindoledione Derivatives

Chakrawarti Prasun, S. R. Wakode


Abstract: Isoindoledione possess a structural featureCO-N (R) -CO-, an imide ring which help them to be biologically active and pharmaceutically useful. Isoindoledione have received attention due to their antibacterial, antifungal, analgesic, antitumor, anxiolytic and anti HIV-1 activities. When Isoindoledione is subjected to Mannich condensation, it yields Mannich bases which may display more biological activities. The increasing popularity of the Mannich reaction has been fueled by the ubiquitous nature of nitrogen containing compounds in drugs and natural products. The aim of the present study is to synthesis Mannich bases of Isoindoledione by Mannich condensation reaction. Isoindoledione reacts with various substituted aromatic aldehydes and substituted amines in presence of mineral acid to give various Mannich bases of Isoindoledione. The synthesized compounds will be characterized by elemental analysis, TLC and structure will confirmed by IR analysis and NMR analysis. Antimicrobial screening of the compounds will be carried out using Serial dilution method.


Keywords: Isoindoledione, Phthalimide, Mannich base, N-Mannich base, antimicrobial activity, parallel synthesizer, MIC


Edition: Volume 4 Issue 1, January 2015


Pages: 2624 - 2628



Make Sure to Disable the Pop-Up Blocker of Web Browser




Text copied to Clipboard!
Chakrawarti Prasun, S. R. Wakode, "Synthesis, Characterization and Evaluation of Antimicrobial Activity of Various Mannich Bases of Isoindoledione Derivatives", International Journal of Science and Research (IJSR), Volume 4 Issue 1, January 2015, pp. 2624-2628, https://www.ijsr.net/getabstract.php?paperid=SUB15866, DOI: https://www.doi.org/10.21275/SUB15866



Similar Articles

Downloads: 0

Research Paper, Chemistry, India, Volume 11 Issue 2, February 2022

Pages: 957 - 959

Evaluation of Antimicrobial Activity of Some Thia-1, 3, 4-Oxadiazolophanes

Varsha V. Thorat

Share this Article

Downloads: 0

Research Paper, Chemistry, India, Volume 11 Issue 7, July 2022

Pages: 125 - 132

Synthesis, Characterization and In Vitro Antimicrobial Evaluation of Some New Benzofuranyl Substituted Pyrido [3, 2-C] Coumarins

Nehakumari N. Gohil, D. I. Brahmbhatt

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Chemistry, India, Volume 11 Issue 1, January 2022

Pages: 1319 - 1324

Design, Molecular Docking, DFT and Antimicrobial Studies of Novel Benzimdazole Derivatives

A. Adhilakshmi, S. Darlin Quine

Share this Article

Downloads: 2 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2

Research Paper, Chemistry, India, Volume 13 Issue 1, January 2024

Pages: 1088 - 1090

Synthesis of Schiff Base Metal Complexes of 1-(2-hydroxy-5-methylphenyl) Ethan-1-One and Benzohydrazide, Their Characterization and Biological Studies

V. A. Sadafale

Share this Article

Downloads: 4 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Chemistry, India, Volume 8 Issue 12, December 2019

Pages: 1977 - 1985

Phytochemistry and Pharmacological Activities of Murraya koenigii (Curry Leaves) Leaves Extracts

Anil Kumar

Share this Article
Top