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Research Paper | Biomedical Sciences | Indonesia | Volume 6 Issue 4, April 2017 | Popularity: 6.9 / 10
The Correlation between Mammaglobin a mRNA Concentration in Peripheral Blood and Clinical Stages of Breast Cancer Patients at Sanglah General Hospital
Suryawisesa I.B.M., Setiawan I.G.B, Widiana I.K, Sudarsa IW, Manuaba I.B.T.W, Gusti NK Mahardika, Utami I.G.A.A.J.W.
Abstract: Its difficult to determine the state of breast cancer after complete treatment by the clinical finding alone. Mammaglobin A mRNA is one of the most simplest promising method in follow-up post-operative due to its specific overexpression for breast cancer. Methods The study design was cross sectional analytic study. The samples consist of 60 breast cancer patients were analysed the peripheral blood by qRT-PCR for Mammaglobin A mRNA. Results The average concentration of Mammaglobin A mRNA is 1902.1287 g/mL. The ANOVA test showed a significant differences of mean concentration of Mammaglobin A mRNA between metastatic and non-metastatic (Average difference concentration 285.71328 g/mL, 95 % CI = 28.20960 543.217). Conclusion Mammaglobin A mRNA concentration was different in metastatic and non metastastatic. Micrometastases could detect as early as possible and quantification of CTC can be done before clinically manifested.
Keywords: Mammaglobin A mRNA, qRT-PCR, Clinical Stages Breast Cancer
Edition: Volume 6 Issue 4, April 2017
Pages: 654 - 658
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