Apixaban Anticoagulation Failure in Patients with Bio-Prosthetic Aortic Valve with Concomitant Paroxysmal Atrial Fibrillation Presenting as LAD Thrombosis, A Case Report

Umar Hayat, Wajih Ullah, Abdur Rehman, Muhammad Yousaf

Abstract: One of the significant risk factor for development of a thromboembolic events in patients with bio-prosthetic aortic valve is co-occurence of paroxysmal atrial fibrillation. Coumadin and New Oral Anti-Coagulants (NOACs) have been used for prevention of these events. Recent studies have shown that NOACs are less potent in preventing these thromboembolic events like stroke and myocardial infarction etc. compared to Coumadin.

Keywords: NOACs New oral Anticoagulants, TE Thromboembolic events, LAD Left anterior descending coronary artery, EKG Electrocardiogram, CAT Scan Computerized tomography, PT Prothrombin time, aPPT activated partial thromboplastin time, INR International normalized ratio