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Research Paper | Microbiology | Iraq | Volume 7 Issue 7, July 2018 | Popularity: 6.4 / 10
Interleukin 10: A Serum Level and Profile of Gene Polymorphism in HBV and HCV Iraqi Patients
Osama B. Al-Saffar, Ali H. Adhiah, Jwan Sabah Bajlan
Abstract: Serum level and gene polymorphism of Interleukin 10 were investigated in 76 Iraqi Arab hepatitis patients; 38 for each of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, as well as 24 ethnicity, age and gender-matched controls. IL-10 was showed significant variations, Serum level of IL-10 was significantly increased in HBV patients compared to controls (22.32 ? 4.09 vs. 18.90 ? 5.49 pg/mL). Distributing patients and controls according to age and gender revealed that there was no significant variation between the age groups < 40 and ? 40 years or males and females. Cytokine gene polymorphism analysis revealed that some genotypes showed a significant departure from Hardy-Weinberg equilibrium in HBV and HCV patients but not in controls. The comparisons between patients (HBV and HCV) and controls revealed some significant variations in the distribution of cytokine genotypes or alleles. IL10-819 CT genotype showed a significant decreased frequency in HBV patients compared to controls, and the PF of such negative association was 0.33. At the three investigated positions of IL10 gene, no significant impact of genotypes was observed, in positions (IL10-1082, IL10-819 and IL10-592), with some exceptions. At IL10-1082, GA and AA genotypes shared a similar mean of IL-10 (22.2 ? 6.5 and 22.6 ? 5.8 pg/mL, respectively) in HBV patients, but both means were significantly higher than the mean of GG genotype (20.6 ? 0.1 pg/mL). For IL10-819, the TT genotype of HBV patients demonstrated a significant increased IL-10 level (24.1 ? 3.9 pg/mL) compared to CC and CT genotypes (21.9 ? 3.1 and 18.5 ? 7.6 pg/mL).
Keywords: Hepatitis B virus, Hepatitis C virus, IL-10, IL10-1082, IL10-819, IL10-592, Gene Polymorphism
Edition: Volume 7 Issue 7, July 2018
Pages: 361 - 366
DOI: https://www.doi.org/10.21275/ART20183831
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