Comparative Study and Tree Construction of Different Organism Based on Histone Family

Akhilesh Lokhande, Dinesh Maske, Yusuf Talib

Abstract: Phylogenetic is one of the branches to study evolutionary study of living organisms, the classification of organism based on basis of similarity. Bioinformatics plays a key role to modulate and enhance the study of sequence similarity and provides the detailed study of each and every sequence and their evolutionary study using the concepts of Phylogenetic tree analysis, the concept help researcher to understand the importance of divergence, time factor, and pedigree of sample sequences. Histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes Genes encoding histone variants are usually not clustered, have introns and their mRNAs are regulated with polyA tails. Five major families of histones existH1/H5, H2A, H2B, H3, andH4. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1/H5 are known as the linker histones.

Keywords: Phylogenetic, Alignment, Histone, Phylogram, Cladogram