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Research Paper | Medicine | Indonesia | Volume 11 Issue 11, November 2022 | Rating: 4.8 / 10

Relationship of Pentraxin 3 Levels with Severity COVID-19 Patients Treated at Haji Adam Malik Hospital Medan

Dara Amelia

Abstract: Background: Coronavirus disease 2019 (COVID-19) is highly contagious and deadly and is associated with organ dysfunction. Pentraxin-3 (PTX3) is a member of the super family of pentraxins and is involved in acute inflammation and the innate immune system. Pentraxin-3 (PTX3) participates in innate resistance to infection and is closely related to the severity of COVID-19. Methods: This research is an observational study with cross sectional data collection method. This study took blood samples of 34 patients with moderate and severe COVID 19 patients being treated at the HAM Hospital. Samples were examined only once for Pentraxin 3 in moderate and severe COVID-19 patients. The research was conducted after obtaining ethical approval and informed consent. Result and Discussion: 22 male patients (64.7%) and 12 female patients (35.3%) with the youngest 32 years old and the oldest 75 years old. By using the enter method in multivariate analysis, only one independent variable was obtained that could predict the severity of COVID-19 disease, namely the level of pentraxin 3 (p=0.015). The results of the analysis using the ROC curve obtained that the AUC area of pentraxin 3 levels in predicting the severity of COVID-19 disease was 81.4% with p=0.003 and 95%I K 65.6%-97.3%. This shows that pentraxin 3 levels can be used to predict the severity of COVID-19 disease with a good level of ability (AUC > 80%-90%). Conclusion and Suggestion: Pentraxin 3 levels can be used as an alternative biomarker to assess the severity of COVID-19, because PTX3 is closely related to the pathogenesis of inflammation and organ dysfunction related to COVID 19.

Keywords: COVID-19, Pentraxin 3, Severity

Edition: Volume 11 Issue 11, November 2022,

Pages: 1132 - 1135