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Masters Thesis | Health and Medical Sciences | India | Volume 11 Issue 12, December 2022 | Popularity: 4.3 / 10
Preparation and Evaluation of Transdermal Films Containing Diltiazem Hydrochloride
Ashitha S
Abstract: Diltiazem Hydrochloride is an antihypertensive drug belongs to the category of calcium channel blockers. The half-life is 3.7 hr, metabolised mainly in the liver and undergoes significant first pass metabolism. The present study is carried out to develop and evaluate a matrix-type transdermal formulation containing Diltiazem hydrochloride with different ratios of HPMC and PVP combination plasticized with PEG (Polyethylene Glycol) by the solvent evaporation technique. The prepared patches were evaluated for their physicochemical characteristic such as thickness, weight variation, drug content uniformity, moisture content, folding endurance, tensile strength. Data of in-vitro release from patches were fit into different equation and kinetic models to explain release of kinetics. The model used were zero order and first order equations and Higuchi and Korsmeyer-peppas models. The promising formulation is subjected to short term stability studies and found to be stable with respect to the physical parameters and drug content. IR studies showed that there is no interaction between drug and polymer and they are found to be compatible.
Keywords: Diltiazem Hydrochloride, HPMC, PVP, PEG
Edition: Volume 11 Issue 12, December 2022
Pages: 234 - 255
DOI: https://www.doi.org/10.21275/MR221129150517
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