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Masters Thesis | Otorhinolaryngology | India | Volume 12 Issue 10, October 2023 | Rating: 5.3 / 10

Diagnostic Efficacy of Thyrotropin to Thyroglobulin Ratio in Correlation with Histopathology in a Euthyroid Patient with Thyroid Nodule

Abstract: Introduction: With increasing rates of thyroid cancer in India, serum markers and their effectiveness in diagnosing the condition needs evaluation. The present study was conducted to compare thyrotropin with thyrotropin: thyroglobulin ratio with regards to their accuracy in the prediction of malignancy in patients with thyroid nodules. Methods: A prospective study was done. Forty-three patients presenting with thyroid nodules and undergoing thyroid surgery had their thyrotropin and thyroglobulin assessed during preoperative assessment. Post-thyroidectomy histopathology of tissue specimen was performed, and correlated between preoperative TSH, Tg, and TSH:Tg ratio. Results: Receiver operating characteristic (ROC) analysis yielded a cut off of 1.12 IU/g for TSH:Tg. The sensitivity, specificity, positive predictive value, positive likelihood ratio and negative likelihood ratio for this cutoff were 75%, 87.18%, 37.50%, 5.85, 0.29 respectively. The odds ratio for malignancy at the cut-off was 20.4. TSH cut-off was obtained at 1.31 micro-IU/ml with a sensitivity, specificity, PPV, PLR, NLR, and OR respectively as 50.0%, 33.33%, 7.14%, 0.75, 1.50, and 0.50. Conclusion: The present study showed that TSH:Tg ratio predicted thyroid malignancy in patients with thyroid nodules with fair accuracy. This ratio can therefore be reliably used in identification ofthyroid malignancies when combined with USG and FNAC.

Keywords: Thyrotropin, TSH, Thyroglobulin (Tg), Tg ratio, Thyroid nodule

Edition: Volume 12 Issue 10, October 2023,

Pages: 619 - 623