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Analysis Study Research Paper | Pathology | India | Volume 13 Issue 12, December 2024 | Popularity: 5 / 10

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Histomorphological Spectrum of CNS Lesion at Tertiary Care Centre

Dr. Ankita Rathod, Dr. Manisha Singh, Dr. Roopam Gidwani

Abstract: Introduction: The annual incidence of central nervous system (CNS) tumors varies from 10 to 17 per 100, 000 people for intracranial tumors and 1 - 2 per 100, 000 people for intraspinal tumors. These tumors can be primary or metastatic, with the majority being primary. CNS tumors are a diverse group of neoplasms that can be classified into different categories based on their histological characteristics. Various factors such as age, race, ethnicity, gender, environmental factors, hormones, and genetics can play a role in the development of CNS tumors. Aims and Objectives: To study the histomorphological types of CNS lesions. To study the incidence of age, gender, and anatomical location, of CNS lesions. To study the frequency of CNS lesions according to the WHO (2021) grading system. Materials and Methods: A retrospective analysis of the histopathology records and clinical case files of total 109 cases were done. History was studied in detail in each case with respect to presenting complaints, site, age, and sex distribution. Specimens were fixed in 10% neutral buffered formalin followed by routine paraffin processing. Staining was done by using hematoxylin and eosin (H&E) stain. Mounting was done with DPX (distyrene, plasticizer, and xylene). Stained slides were examined under a light microscope. Reporting and diagnosis of CNS lesions were done as per WHO 2021 criteria. Results: In present study, a total of 109 cases of CNS lesions were studied histologically in which 63 patients were female (57.79%) and 46 patients were male (42.20%) Overall Male to Female ratio was 0.73/1. The neoplastic lesion was 75.3% and non neoplastic lesion was 24.7%, Neoplastic lesion was more frequent than non neoplastic in the present study.

Keywords: CNS lesion, Histopathology, WHO classification

Edition: Volume 13 Issue 12, December 2024

Pages: 145 - 148

DOI: https://www.doi.org/10.21275/MR241130095956

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